A serious injury accident closed State Route 274 between Township Road 94 and County Road 61 (near Lewistown) for about 90 minutes Thursday morning around 7:20.
The Logan County Sheriff's Office responded to a two-vehicle crash in front of 8607 State Route 274.
Deputies report that a 2004 Honda Accord exiting a driveway pulled in front of an eastbound 2003 Chevy pickup.
The driver of the Accord was transported from the scene by LifeFlight to St. Rita's Medical Center in Lima.
The driver of the pickup was transported to Hardin Memorial Hospital in Kenton.
Authorities have not released any names.
The Indian Joint Fire District and Indian Lake EMS assisted at the scene.
Deputies continue their investigation.